Sir Elton John, 72, was due to perform at Bankers Life Foundation in Indianapolis but has had to postpose the gig due to sickness.
The Candle in the Wind hitmaker announced the news on his Twitter account and said he “hated” letting his fans down but it was not “possible” to perform.
He wrote: “To my dear fans in Indianapolis, It is with the heaviest heart that I’m forced to deliver the news that I am extremely unwell and therefore unable to perform at @TheFieldhouse tonight.”
In a follow-up post, Elton said: “I absolutely hate to let my fans down, but I owe it to you to put on the best #EltonFarewellTour show possible and unfortunately that’s simply not possible.”
Sir Elton explained the show has been postponed until next year, as he thanked his fans for their support.
He added: “The date will be rearranged for March 2020, and I promise I will deliver the show you deserve. Thank you so much for your support and understanding. Elton x.”
The day before, Sir Elton’s husband, David Furnish, announced his mum had died and paid tribute to her in an Instagram post calling her an “angel”.
David said his mum, Gladys Furnish, died peacefully surrounded by her family.
He uploaded a picture from her wedding day along with the caption: “Today I lost my beautiful, angelic Mother. She passed away peacefully in the middle of the night, with me and my brothers by her side.
“Mum radiated gentle kindness. She was utterly devoted to her family. We all richly benefited from her patient wisdom and bountiful love.
“I treasure this photo of Mum and Dad on their wedding day – bursting with joy and fresh-faced optimism over their union and the life they planned to build together.
“They shared the greatest love I have ever known; A rock-solid foundation from which my brothers and I flourished.”
He added: “Rest in peace Mum. You lived your life impeccably. I will never forget you. I promise to do my best to pass the gifts you gave to me on to my own beautiful sons.”
Meanwhile, Sir Elton opened up about his health issues in his newly released autobiography, Me: Elton John Official.
The Rocketman singer explained he underwent surgery for prostate cancer two years ago.
But months later, Sir Elton caught a serious infection whilst touring in South America, which left him “close to death”.
The singer was rushed to the UK where they discovered he was worse than they realised, and doctors even told his husband David he was “24 hours away” from dying.
In an interview with Angie Greaves, which aired on Smooth Radio, Sir Elton gave an update on his health, where he stated “there’s hardly any of me left”.
“I’m super fit, I’m super lucky, I’m, you know, there’s hardly any of me left,” he told radio host Angie.
“There’s no tonsils, there’s no prostate, there’s been kidney stones flying out. You know, there’s no appendix, there’s no hair.”
Sir Elton added: “What can I tell you, I am just a shell of a man.”